The effects of probiotic supplementation on markers of blood lipids,And blood pressure in patients with prediabetes: A randomized clinical trial

Methods: this randomized controlled trial consisted of 60 prediabetic patients,aged 25-65 years old,that were randomly assigned to the intervention (receiving 500 mg probiotic capsules,n = 30) or control group (receiving placebo,n = 30) for 8-week period. demographic and anthropometric data were collected at baseline. blood samples were collected at baseline and after 8 weeks for biochemical measurements. blood pressure was measured at the baseline an after 8 weeks of intervention. data regarding dietary intakes and physical activity were also collected during the study. we used spss software version 16 (spss inc. chicago,usa) for data analyzing.results: probiotic supplementation did not contribute to significant changes in total cholesterol,low-density lipoprotein (ldl)-cholesterol,high-density lipoprotein (hdl)-cholesterol,triglycerides (tg),tg/ldl and ldl/hdl ratios,after 8 weeks. after adjusting for potential confounders,hdl-cholesterol reduced significantly in the placebo group compared with probiotic group. percent change in systolic blood pressure was significantly different in the probiotic group in comparison with a placebo group (-3.10 ± 2.22 vs. 3.24 ± 1.96,p = 0.01),although this significance did not exist anymore after adjusting for confounders (p > 0.05).conclusions: our study showed that probiotics did not have significant effects on lipid markers although they had positive effects on systolic blood pressure.background: prediabetes is a high-risk condition for type 2 diabetes mellitus. the growing prevalence of diabetes emphasizes on the necessity of concentrating on various strategies to prediabetes prevention and management. probiotics as a group of functional foods might exert antidiabetic effects. this study aimed to assess the effects of probiotic administration on blood lipid profile and blood pressure in patients with prediabetes. © 2014,isfahan university of medical sciences(iums). all rights reserved.