The effect of 12-week of aerobic training on homocysteine,lipoprotein a and lipid profile levels in sedentary middle-aged men

Background: the purpose of this study was to investigate the effect of 12-week of aerobic training on homocysteine,lipoprotein a and lipid profile levels in sedentary middle-age men. methods: this was a quasi-experimental study. subjects of the study were 24 men (age 40-60) who participated is the study voluntarily and were randomly assigned in aerobic (n = 12) and control (n = 12) groups. the subjects participated in progressive aerobic training on treadmill 3 times a week (20 min/session (60% maximum heart rate) to 60 min (75% maximum heart rate). homocysteine,lipoprotein a,triglyceride (tg),cholesterol,low-density lipoprotein (ldl) and high-density lipoprotein (hdl) were measured before and after 12-week. data were analyzed using paired t-test and independent t-test statistical methods. results: research findings showed a significant decrease in homocysteine (p = 0.002),lipoprotein a (p = 0.003),tg (p = 0.008),cholesterol (p = 0.024) and ldl (p = 0.019),significant increase in hdl (p = 0.017) in posttest compared to pretest. furthermore,research findings showed that homocysteine (p = 0.005),lipoprotein a (p = 0.001),tg (p = 0.006),cholesterol (p = 0.015),ldl (p = 0.022),and hdl (p = 0.004) levels between the two groups. conclusions: these findings reveal the 3 sessions/week of aerobic training cause reduction of homocysteine,lipoprotein a,and lipid profile levels in sedentary middle-aged men and can be recommended for prevention of cardiovascular disease.