Psychosocial determinants of health-related quality of life of people living with HIV/AIDS on antiretroviral therapy at Udupi District,Southern India

Background: life expectancy of people living with hiv/aids (plha) on antiretroviral therapy has appreciably increased. however,psychosocial challenges pose a great threat to their health-related quality of life (hrqol). the aim of this study was to determine psychosocial factors influencing health-related quality of life of plha on antiretroviral therapy. methods: a cross-sectional study was conducted using convenience sampling to select 226 plha at district hospital. demographic information was collected using a semistructured questionnaire. hrqol was assessed using whoqol-hiv bref. the hospital anxiety and depression scale,cage scale,and multidimensional scale of perceived social support were used. one-way anova was applied. results: there was a significant difference in mean quality of life score with respect to level of anxiety in the physical (p < 0.001),psychological (p <0.001),level of independence (p <0.001),social relationships (p = 0.047),environment (p <0.001),and spirituality domain (p < 0.001). significant difference in mean quality of life score was observed with respect to level of depression in physical (p = 0.003),psychological (p = 0.036),level of independence (p = 0.017),social relationships (p = 0.019),and spirituality (p = 0.001). friend support was positively associated with hrqol in physical (p < 0.001),psychological (p <0.001),level of independence (p = 0.013),social relationships (p <0.001),environment (0.001),and spirituality domain (0.026). family support was positively associated with hrqol in physical (p = 0.001),psychological (p =0.001),level of independence (p = 0.040),social relationships (p = 0.008),environment (0.001),and spirituality domain (0.026). a significant difference was observed with respect to affiliation to social organization in social relationships domain (p = 0.044). conclusions: psychosocial challenges including anxiety,depression,and social support impact upon all domains of hrqol of plha.