LDL Particle Size and Reactive Oxygen Metabolites in Dyslipidemic Patients

Objectives: small dense low?density lipoprotein (sdldl) whichhas a small ldl particle size with greater susceptibility to oxidationis regarded as a risk marker for cardiovascular disease. thediacron reactive oxygen metabolites (d?roms) test has recentlybeen introduced as an oxidative stress?related marker in the clinic.the aim of the present study was to investigate the correlationbetween the mean ldl particle size and the oxidative stress statusas evaluated by the d?roms in dyslipidemic patients.methods: the study included 278 dyslipidemic patients (121 maleand 157 female, mean age, 60 years). clinical data including theconventional atherosclerotic risk factors in addition to the meanldl particle size measured with the gel electrophoresis and thed?roms were collected.results: male patients had a significantly smaller mean ldl particlesize than females (262.2 ± 7.5 [sd] vs. 264.3 ± 6.7 ?, p < 0.05), whilefemale patients had a significantly higher d?roms level than males(318 ± 68 vs. 350 ± 72 u. carr., p < 0.01). a multiple regressionanalysis revealed that there was an independent, significant, andinverse correlation between the mean ldl particle size and thed?roms (b=?0.19, p < 0.05).conclusions: these findings of the co?existence of both markerssuggest that sdldl and oxidative stress can be cooperative inatherogenesis, possibly leading to the incidence of cvd, indyslipidemic patients.