Efficacy of Enalapril in Migraine Prophylaxis: A Randomized, Double-blind, Placebo-controlled Trial

Background: some angiotensin converting enzyme (ace) inhibitorshave previously been shown to be effective in migraine prophylaxis.the aim of this study was to evaluate whether enalapril is effective inmigraine prophylaxis.methods: in this randomized, double?blind, placebo?controlled clinicaltrial, the effects of 10 mg enalapril given daily were compared with thoseof matched placebo in 40 migraineurs for 2 months. response to treatmentwas assessed at 0, 1, and 2 months after the start of intervention accordingto headache parameters like frequency, severity, and duration. this trialis registered with iranian registry of clinical trials (irct), numberirct138711011570n1.results: a significant effect on reducing migraine attack more than50% at first and second months (p=0.016) occurred in enalapril group.indeed, at the first and second months of treatment, the severities(p=0.000 and p=0.000) and duration (p=0.037 and 0.003) in the enalapriltreated group were significantly lower than in the placebo group.conclusion: enalapril may be effective in migraine prophylaxisaccording to its effect in decreasing the frequency, severity, and durationof headaches. the results support the previous suggestions on usage oface inhibitors in migraine prophylaxis.