Preventive and Curative Effects of Ginger Extract Against Histopathologic Changes of Gentamicin-Induced Tubular Toxicity in Rats

Background: gentamicin (gm) is a commonly used aminoglycoside,however, renal toxicity has limited its usage. this study was designed toevaluate the curative and protective effects of zingiber officinale (ginger)against gentamicin tubular toxicity in rats. the phenolic and flavonoidcomponents and antioxidant activity of ginger were also evaluated.methods: in a preclinical study, 50 male wistar rats were designatedinto 5 groups of 10 and treated as follows: group i: vehicle. group ii:200 mg/kg/d of ginger for 3 days then, gm (80 mg/kg) for 7 days.group iii: 200 mg/kg ginger orally for 3 days, then ginger plus gm for7 days. group iv: gm for 7 days. group v: gm for 10 days. group vi:gm for 7 days, then 200 mg/kg ginger orally for 10 days. at the end ofthe study, the animals were sacrificed and their kidneys were histologicallyevaluated. results: ginger could prevent degeneration of the renalcells and reduce the severity of tubular damage caused by gentamicin.however, it could not regenerate the gm degeneration.conclusions: the results indicate that ginger is effective as aprophylaxis agent, but has not curative effect.