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estimating the prevalence of positive tuberculin skin test reactions in general population and high-risk groups: a meta-analysis
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نویسنده
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rezai mohammad sadegh ,tabrizi reza ,haghdoost ali akbar ,afshari mahdi ,abedi siavosh ,akbari maryam ,bahrami mohammad amin ,moosazadeh mahmood
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منبع
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international journal of preventive medicine - 2017 - دوره : 8 - شماره : 11 - صفحه:55 -61
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چکیده
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Results of tuberculin skin test (tst) surveys among different populations have been reported in many studies as a method for detecting primary mycobacterium tuberculosis infection. combining these results provides reliable estimates of primary latent tuberculosis (tb) infection for health policymakers. this study aims to estimate the prevalence of latent tb infection in general and high‑risk populations in iran. national and international databanks were searched using specific keywords. after restricting the search strategy, duplicates exclusion, reviewing titles, abstracts and full texts, and quality assessment, eligible papers were selected. the heterogeneity between the results was assessed according to cochrane and i‑squared indices. the prevalence of positive tst reactions was estimated using fixed and random effect models. totally, 33 papers were entered into the meta‑analysis reporting the tst results in 12693 people aged over 18. the prevalence (95% confidence intervals) of positive tst reactions in all groups, general population, health staff, medical students, household close contacts, patients with tb, immunocompromised patients, hiv/aids patients, and those with risky behaviors was 26.2% (19.6–32.8), 25.4% (4.8–46.1), 38.9% (27.4–50.9), 13.4% (9.9–16.7), 35.9% (16.4–55.5), 13.7% (8.4–18.9), 29.4% (21.2–37.7), and 14.6% (3.9–25.3), respectively. our study showed great varieties of positive tst results among different iranian subpopulations. furthermore, the prevalence of latent tb infection among health professionals and family members of tb patients was considerably different from that of the other subgroup. since tb control programs such as active case finding are routinely conducted among household close contacts and hiv/aids cases, other high‑risk groups including health‑care workers and immunocompromised patients should be taken into consideration in these preventive programs. keywords:
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کلیدواژه
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latent tuberculosis ,purified protein derivative ,tuberculin skin test ,tuberculosis
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آدرس
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mazandaran university of medical sciences, infectious diseases research center with focus on nosocomialinfection, iran, shiraz university of medical sciences, institute of health, student research committee, health policy research center, iran, kerman university of medical sciences, institute for future studiesin health, modeling in health research center, iran, zabol university of medical sciences, department of community medicine, iran, mazandaran university of medical sciences, department of internal medicine, iran, shiraz university of medical sciences, institute of health, student research committee, health policy research center, iran, shahid sadoughi university of medical sciences, departmentof healthcare management, iran, mazandaran university of medical sciences, addiction institute, health science research center, iran
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پست الکترونیکی
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mmoosazadeh1351@
gmail.com
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Authors
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