Type of Aerobic Training Effect on Cardiac Muscles MIR29A and Collagen I Gene Expression in Diabetic Male Rats

Objective: high intensity interval training (hiit) and continues aerobic training have cardio-protective effects in diabetic rats. the aim of this study was to compare the effect of hiit and continues aerobic training (cat) on mir29a and collagen i gene expression in heart of diabetic male rats.materials and methods: in this randomized controlled clinical trial, 18 male diabetic rats were studied. they were divided into 3 groups as hiit, cat and control group. exercise protocol was performed 5 days/week for 5 weeks. the mir29a and collagen i synthesis were compared between the groups.results: findings showed mir29a expression is statistically higher in hiit and cat group than control group (p-value<0.001) and (p-value:0.053). also mir29a expression is significantly higher in hiit group compared to cat group (p-value:0.034). collagen i expression was significantly lower in hiit and cat group compared to control group (p-value<0.001) and (p-value:0.001). collagen i expression was lower in hiit group compared to cat group (p-value:0.027).discussion: the results of this study demonstrated that, hiit increases mir29a expression which is along with reduction in collagen i synthesis in cardiac muscles increases the risk of myocardial fibrosis in diabetic rats.