oxidized ldl is correlated with urine albumin in type 2 diabetes mellitus: a case-control study

Objective: in patients with diabetes mellitus, increased rate of lipoprotein oxidation and oxidative stress have important role in diabetic angiopathy, including nephropathy. we designed a study for comparing the level of ox-ldl in diabetic patients with macro-albuminuria, micro-albuminuria, versus normo-albuminuric.materials and methods: one hundred and thirty five patients with type 2 diabetes mellitus who had been referred to the yazd diabetes clinic, from 1391 through 1392, were enrolled to our study. the 24 hours urinary albumin excretion was measured and macro-albuminuria defined as albumin excretion of greater than 300mg per day and below 30mg per day in normo-albuminuric group and between 30-300mg defined as micro-albuminuria group. plasma level of ox-ldl was measured.results: the plasma ox-ldl level in patients with macro-albuminuria was higher than those in normo-albuminuric group, (16.1±3.6 u/ml versus 8.6±1.7 u/ml). there was a significant correlation between the ox-ldl and urine albumin in macro-albuminuria and micro-albuminuria groups. there was no significant correlation between the ox-ldl and hba1c level and diabetes duration.conclusion: significantly elevated plasma ox-ldl in patients with macro-albuminuria suggests that ox-ldl may play an important role in the progression of diabetic nephropathy.