Prevalence of Anti Hyperglycemic Agents -Associated Oral Lichenoid Lesions in Type 2 Diabetes Mellitus Patients

Objective: this study aimed to estimate the prevalence of lichenoid reactions to anti hyperglycemic agents.materials and methods: in this cross-sectional descriptive and analytic study, we examined the oral mucosa of 411 patients at the age of 29 to 85 in 3 groups who consumed various antihyperglycemic agents.results: in overall, 31 patients had lichenoid reactions (12 patients taking glibenclamide, 1 patient taking metformin and 18 patients taking glibenclamide with metformin) and there was a significant difference between the groups (p = 0.013). the most of the lesions were at the age's upper than 60 years. from 31 patients with lichenoid reactions, 14 subjects (45%) were male and 17 subjects (55%) were female.conclusion: prevalence of lichenoid reactions in this study was 7.5% approximately. by considering the significant difference among the groups in the incidence of lesions, the significant effect of glibenclamide in inducing lichenoid reactions can be considared.