effects of lipoic acid and high-intensity interval training (hiit) on pancreatic vegfr-3 levels in diabetic rat model

Objective: the purpose of this experimental research is to investigate the effects of high-intensity interval training (hiit) and lipoic acid )ala( supplementation on vegfr-3 of pancreatic in diabetic wistar rats model. materials and methods: 20 male wistar rats weighing 159 ± 3 gr and aged3 weeks, were randomly assigned into 4 groups:1) diabetes/sham, 2)diabetes/ ala, 3)diabetes/exercise/sham, and 4) diabetes /exercise/ ala. diabetes was induced with streptozotocin (65 mg/kg dose) and nicotinamide (120 mg/kg dose). after two weeks of familiarization with interval training, the rats started their main training, included 10 repetitions of 4 minutes of running on the treadmill with an intensity of 85-90% vo2max and 2 minutes of active rest between repetitions (5-10 m/min) for 5 sessions per week for 6 weeks. ala supplement was taken at a dose of 20 mg/kg/day for 6 weeks. one-way anova test used and tukey’s post hoc test at for analysis (p≤ 0.05). results: hiit has a significant effect on blood glucose (p= 0.004) and insulin (p= 0.001) and vegfr3 (p= 0.001) of pancreatic tissue of diabetic rats. conclusion: lymphatic vessels play an important role in the pancreas and treat diabetes.the results of this research showed that hiit and ala increased lymphangiogenesis in the diabetic rat model.