Comparative Efficacy Study of N-Chromosome Royal Jelly Versus Semelil (Angipars) on Wound Healing of Diabetic Rats

Objective: the healing effects of two different dilutions (5 & 100%) of n-chromosome royal jelly and angipars ointment were investigated and measured on experimental injuries in streptozotocin (stz)- induced diabetic rats. this study investigated the healing effects of 2 different n chromosome royal jelly dilutions on injuries of stz-induced diabetic rats. materials and methods: for diabetes induction, male wistar rats received stz (55 mg/kg) intraperitoneally and plasma glucose level measurement after 72 hours demonstrated diabetes induction. rats were randomly divided into 5 groups of 6 members and one square centimeter (cm2) wound was surgically induced in the dorsal region of each rat. the test groups were treated with angipars, undiluted royal jelly n chromosome, and royal jelly n chromosome 5% separately. the control groups were including non-diabetic and untreated diabetic rats. results: the findings indicate a significant acceleration in wound healing of the diabetic rats treated by angipars ointment or royal jelly n chromosomes 5%. rj also shortened the healing period of desquamated skin lesions. thus, rj possesses an anti-inflammatory action and is able to augment wound healing, but does not have an insulin-like action in streptozotocin-diabetic rats. conclusion: regarding the mentioned findings, royal jelly as a natural product may play an effective role in treating chronic wounds in mice, which makes it a proper candidate for use in human wound repair. nonetheless, it seems that determination of the suitable dilution of this compound will result in better effects, thus more studies are recommended.