The Comparison of the Protective Effect of L-Carnitine, Chromium and Vitamin D With Metformin on Liver, Antioxidant Enzyme Activity, and Iron Metabolism in Diabetic Rats

Objective: due to the lack of information about the positive or negative effects of l-carnitine, chromium, vitamin d, and the uptake of a safe dietary supplement to reduce the effects of diabetes, it seems essential to determine the effects of these drugs on diabetes. materials and methods: wistar rats were divided into 12 groups, control, diabetic, and intact, each of which was treated with metformin, l-carnitine, vitamin d, and chromium or a combination of l-carnitine, vitamin d, and chromium. the serum levels of liver function parameters, iron, tibc, catalase and gpx activities were measured. data were statistically analyzed by one-way anova using spss 18 software. statistical significance among the groups was determined using lsd test, and p-value< 0.05 was considered significant in all cases. results: ast activity in diabetic groups and those receiving chromium and l-carnitine has significantly reduced (p-value= 0.009). a significant reduction in alt and alp activity in the diabetic groups receiving vitamin d and combined and non-diabetic groups receiving metformin were observed, in contrast to a significant increase in alt activity in diabetic recipients of lcarnitine (p-value= 0.009). conclusion: l-carnitine, chromium, and vitamin d supplements have synergistic effects and a combination of them has the best protective effect on factors that have been studied.