the effect of aerobic training on tumor necrosis factor alpha, hypoxia-inducible factor-1 alpha & vascular endothelial growth factor gene expression in cardiac tissue of diabetic rats

Objective: the goal of this research was to determine the influence of 4 weeks aerobic training on gene expression of tumor necrosis factor alpha (tnf-α), hypoxia-inducible factor-1 alpha (hif-1α) andvascular endothelial growth factor (vegf) in the cardiac tissue of diabetic rats. materials and methods: in an experimental study, 30 male wistar rats were partitioned into three groups (n=10), diabetic aerobic training, diabetic control and healthy control (n=10).induction of type 2diabetes (t2dm) was done by intraperitoneal infusion of streptozotocin. the progressive aerobic training protocol entailed 4 weeks, 5 sessions per week running on treadmill at velocity of 20 m/min for 60 min. the gene expression of tnf-α,vegf and hif-1α were measured by real time & pcr. one way analysis of variance and bonferroni test were applied to analysis the data. the significant level was set at p-value< 0.05. results: the results indicated that the aerobic training induced significant decrease in tnf-α mrna (p-value< 0.001) andsignificant increase in hif-1α mrna (p-value< 0.001) and vegf mrna (p-value< 0.001) compared to diabetic control group. conclusion: it appears that aerobic training with reduction of tnf-α issues an affirmative effect on angiogenesis, as a result, it improves diabetic cardiac.