the effect of high intensity intermittent training (hiit) on glp-1r expression in pancreas tissue and serum insulin of male wistar rats with type 2 diabetes mellitus

Objective: insulin secretion and insulin resistance are associated with incidence and severity of type 2 diabetes mellitus (t2dm). this study aimed to assess the effect of high intensity intermittent training (hiit) on glp-1r expression in pancreas tissue and serum insulin of t2dm rats. materials and methods: in this quasi-experimental study, t2dm induced by intraperitoneal injection of streptozotocin-nicotinamide in 16 male wistar rats aged 10 weeks (220 – 20 g). therats were divided into control (no-training, n= 8) and hiit (5 times/week/12-week, n= 8) groups. glp-1r expression in pancreas tissue, fasting glucose and serum insulin were measured 48 h after lasted exercise of exercise and control groups. independent and paired ttest was used to compare variables between 2 groups. results: hiit resulted in significant increase in glp-1r expression compared to control subjects (p-value: 0.023). fasting glucose decreased (p-value< 0.0001) and serum insulin increased (p-value< 0.0001) in response to hiit when compared to control subjects. conclusion: hiit can improve insulin secretion in male rats with t2dm and this improvement can be attributed to increased glp-1r expression in pancreas tissue in response to training protocol.