the effect of combined exercise course and aloe-vera supplementation on renal function and lipid profile in type 2 diabetes mellitus patients: a randomized clinical trial

Objective: renal failure is a complication of diabetes. it can be the risk factor of cardiovascular disease. this study aimed to evaluate the effect of exercise course and aloe-vera supplementation on renal function and lipid profile in type 2 diabetes mellitus (t2dm) patients.materials and methods: this is a clinical trial double blind with pre-test and post hoc test analyses with a control group. the studied population included a group of t2dm diagnosed patients among whom 24 men (40-60years) were selected voluntarily andpurposefully and were classified into three groups by balanced block randomization method, exercise(e), exercise + supplement (e+s), and control (c), (n=8/group). combined exercise was planned in two12-minute repetitive sets with 70% 1rm. then the participants ran for two 10- minute sets with 70-75% maximum heart rate intensity on treadmill. e+s participants consumed 500 mg/day aloe vera for6 weeks. obtained data by spss-19 software were analyzed using co-variance analysis method with bonferroni post hoc test (pvalue< 0/05). results: results showed that e and e+s significantly improvedgfr (p-value=0.011) and e with or without aloe-vera consumption decreased creatinine levels (p- value=0.042) and increased hdl levels (p- value˂0.001). the results demonstrated that ldl and tg levels showed no significant difference in reaction to the combined exercise and supplementation. conclusion: combined exercise along with aloe-verasupplementation has had significant effect on improving renal factors and lipid profile of t2dm diagnosed patients.