itamin d deficiency and psoriasis: a cross-sectional study of iranian population in yazd province

Objective:psoriasis is an inflammatory disease of the skin and the joints. psoriatic patients sometimes suffer from vitamin d deficiency and hypocalcemia. the aim of our study was to evaluate the level of calcium and vitamin d in patients with psoriasis. materials and methods: in this analytical cross sectional study, 110 cases of psoriasis that were referred to shohadaye mehrab clinic during 2015 and 110 non-psoriatic patients enrolled. serum levels of calcium, phosphorus, parathyroid hormone (pth), alkaline phosphatase (alk) and 25- hydroxy vitamin d3 [(25oh) d3] were measured in both groups. data were analyzed using spss software version 19. chi square test and t-test were used for statistical analysis. results:among110 patients with psoriasis 74 (67.3%) were men and 36 (32.75%) were women. there was no significant difference in the serum level of calcium (p-value: 0.563), phosphorus (p-value: 0.381), pth (p-value: 0.364) and alk (p-value: 0.639) between two groups. vitamin d deficiency was found in 64.5% of psoriatic patients and 60% of the controls (p-value= 0.45); however 30.9% of psoriatic and 17.3% of the controls suffered from severe hypovitaminosis d. this difference was statistically significant (p-value= 0.014).conclusion:we found a significant relationship between severe hypovitaminosis d and psoriasis. this finding revealed the need for evaluation of psoriatic patients for the presence of vitamin d deficiency.