effect of interval and continued exercises with crocin on bax/bcl-2 in diabetic obese rats

Objective: diabetes is a metabolic disease which is linked to increased physical disabilities and muscle tissue damage. the aim of this study was to investigate the effect of interval and continued exercises with crocin on bax/bcl2 ratio in diabetic obese rats.materials and methods: in this clinical trial study, 56 adult diabetic rats (highfat diet and venous injection of streptozotocin) were selected and randomly assigned to groups (1), intense interval exercises (2), low intensity exercise (3), intense interval exercise with crocin consumption, (4) low intensity exercise with crocin consumption, (5) crocin consumption, (6) sham and (7) control were divided. intense interval and low intensity exercise groups lasted for 8 weeks, three sessions per week, with intensity of 80 to 85 and 50 to 55 percent of maximum treadmill running, and crocin consumption groups for 8 weeks per day, mg / kg 25 crocin were taken peritoneal. to analyze the research hypotheses, kolmogorov smirnov tests, independent t tests and twoway multivariable analysis of variance were used along with benferron's comparison method. it should be noted that the significance level in all measurements was considered to be pvalue ≤ 0.05.results: results showed that exercise (pvalue: 0.12) and crocin (pvalue: 0.10) consumption had no significant effect on bax/bcl2 gene expression in diabetic rats. also interaction of exercise and crocin consumption on bax/bcl2 was not significant (pvalue: 0.12).conclusion: it appears that exercise and crocin consumption have not interaction effect on improvement of bax / bcl2 ratio in diabetic rats.