effect of 6 weeks of high intensity interval training with nano-curcumin supplement on antioxidant defense and lipid peroxidation in overweight girls- clinical trial

Objective: thepurpose of this study was to investigate the effect of 6 weeks of hiit training combining nanocurcumin supplement on antioxidant defense and lipid degradation in overweight girls.materials and methods: the research method was semiexperimental study. accordingly, 48 overweight girl students were randomly divided into four groups: training (n=12), trainingsupplement (n=12), supplement (n=12) and control group (n=12). supplement groups consumed 80 mg nanocurcumin capsule daily. training groups performed an exercise protocol of hiit training with maximum heart rate for 6 weeks (three sessions per week). the control group did not have any regular exercise. blood samples were obtained before and after training period for antioxidant indicators and lipid degradation measurement. ttest and oneway analysis of variance were used for the evaluation of withingroup and betweengroup differences, respectively. results: a significant increase was observed in serum levels of malondialdehyde (pvalue= 0.004) in the training group after 6 weeks. also, there was a significant increase in serum glutathione (pvalue= 0.001), superoxide dismutase (pvalue= 0.006) and catalase indexes (pvalue= 0.01) in the supplement group. moreover, a significant increase in catalase (pvalue= 0.001), glutathione (pvalue= 0.006), superoxide dismutase (pvalue= 0.015) and glutathione peroxidase indexes (pvalue= 0.05) and a significant decrease in malondialdehyde (pvalue= 0.009) were observed in the training supplement group.conclusion: a positive antioxidant effect was seen, so taking curcumin supplement along with exercises may have beneficial effects on reinforcement the antioxidant system and prevention of lipid peroxidation in overweight individuals.