The Evaluation of Serum Level of Testosterone and Sex Hormone- Binding Globulin in Men with Type 2 Diabetes

Objective: to evaluate the relationship between serum level of testosterone and sex hormone-binding globulin in men with type 2 diabetes. materials and methods: in this case-control study, forty men aged 40-70 with type 2 diabetes mellitus were randomly selected and compared with 40 non-diabetic men. the two groups were matched for their age and bmi. after complete observation and examination, fasting blood sugar, postprandial blood sugar, total and free testosterone, sex hormone-binding globulin and hba 1c were measured. results: the mean serum level of total testosterone was 9.65 ± 2.16 mg/dl in diabetic patients and 12.77 ± 3 mg/dl in non-diabetic subjects which was significantly different (p = 0.0001) . the mean value of free serum level of testosterone was significantly higher in nondiabetic group (14.96 ± 4.97 mg/dl) in comparison with diabetic group (9.55 ± 8.14 mg/dl, p = 0.0001). conclusion: in this study we found a lower level of total testosterone, free testosterone, and in lesser extent sex hormone-binding globulin in men with type 2 diabetes comparing to nondiabetic men.