Effect of Vitamin E on Blood Glucose, Lipid Profileand Blood Pressure in Type 2 Diabetic Patients

Objective: type 2 diabetes is associated with elevated oxidative stress and decline in an tioxidant defense. vitamin e supplementation reduces oxidative stress level in diabetic patients.purpose of this study was to evaluate the effect of vitamin e supplementation on glycemic control and lipid profile in type 2 diabetic patients.material and methods: in this study 31 type 2 diabetic patients with fasting bloodsugar (fbs):140-200 mg/dl, triglyceride (tg): 200-400 mg/dl, cholesterol (tc): 200-300mg/dl and mild hypertension were selected. subjects received vitamin e 800 iu/day for 3 months. at the baseline and end of the study fbs, tc, tg, ldl, hdl, glycated hemoglobin and fasting insulin level were measured.results: in this study 31 type 2 diabetic patients (19 female, 12 male) with mean age 53.03 ±8.87 years were studied. vitamin e supplementation for 3 months had no positive effect on type2 diabetic patients. as fbs, tg and fasting insulin decreased but this decline was not significant.also total cholesterol, systolic and diastolic blood pressure changes were not remarkable.conclusion: results of this study showed that 800 iv vitamin e administration for 3 months could not improve blood glucose, lipids, hbalc, fasting insulin, systolic and diastolicbp in type 2 diabetic patients.