the effect of aerobic training and l- carnitine on bcl2 and mitochondrial enzymes of rat's kidney

Objective: diabetes causes free radical production, oxidative stress and alterations in mitochondrial enzymes and apoptosis. the purpose of this study was to investigate the effect of aerobic exercise and consumption of l-carnitine on bcl2 and some mitochondrial enzymes of the kidney in diabetic rats. materials and methods: in this experimental study, 45 male wistar rats (200-300 gr) were simple randomly divided into six groups: 1) placebo group, 2) healthy control group, 3) diabetic control group, 4) diabetic group receiving l- carnitine, 5) diabetic group of aerobic training and 6) diabetic group of aerobic training and recipient of l-carnitine. rats with a serum glucose level higher than 300 mg/ dl were considered diabetic. l-carnitine recipients received 100 mg of l-carnitine daily orally. the dependent variables of the study were measured 24 hours after the last training program session by elisa in kidney tissue. data were analyzed by shapiro- wilk and two way anova and tukey post hoc test at p-value< 0.05. results: the results showed that the combined effect of aerobic training and supplementation of l-carnitine on bcl2 factor of kidney tissue of rats with diabetes has a significant effect (p-value: 0.019). but aerobic exercise (p-value: 0.969) and supplementation of lcarnitine (p-value: 0.584) were not significant. conclusion: the results of this study showed that the combined effect of aerobic exercise and supplementation of l-carnitine on cpt2 and malonyl coa and bcl2 have a significant effect on the kidney of diabetic rats. also, exercise alone and consumption of lcarnitine alone do not have a significant effect.