the effects of six weeks endurance training on xbp-1 protein in the diabetic male wistar rats sciatica tissues

Objective: the aim of this study was to investigate the effect of endurance activity on xbp-1 protein content in sciatica tissue of diabetic male wistar rats. materials and methods: the experimental design was a posttest design with control group. in this study, 32 male wistar 10 weeks old rats with the mean weight of 253.16 (±10.16) grams were randomly divided into four groups: healthy control, healthy exercise, diabetic control and diabetic training group. an intraperitoneal injection of stz (45 mg / kg) solution was used to induce diabetes after 12 hours fasting, 48 hours after stz injection, the moderateintensity endurance protocol was performed for 6 weeks. twentyfour hours after the last training session, the mice were exposed and their sciatic nerve was extracted. the amount of xbp-1 protein was measured by elisa method. for statistical analysis, spss software and two-way anova with repeated measure and independent t-test were used. results: data analysis showed that endurance activity had an effect on the amount of xbp-1 protein and reduced the protein content, so that the difference was significant in the diabetic training group compared to the diabetic control group (p-value: 0.007). conclusion: these findings indicated that moderate aerobic exercise has a significant effect on the amount of xbp-1 protein in healthy and diabetic rats.