the effects of high intensity interval training on hnf-4 α gene expression in liver tissue of type 2 diabetic male wistar rats

Objective: this study examined the effect of high intensity interval training (hiit) on hnf-4α gene expression, glucose and insulin in liver tissue of type 2 diabetic male wistar rats. materials and methods: in this study, 20 male wistar rats weighing 220 (±20) grams were selected. after type 2 diabetes (t2d) induction, the samples were divided into two groups of hiit and control. the training program was 12 weeks and 5 times a week. fasting glucose, serum insulin and hnf-4α gene expression in the liver tissue were measured in both groups after the last exercise session by using independent t-test. results: the results showed that hiit decreased significantly the fasting glucose (p-value: 0.001) and increased serum insulin (pvalue: 0.001). also, the expression of hnf-4α after hiit significantly decreased in comparison to the control group (p-value: 0.003). conclusion: based on the findings, hiit resulted in a significant decrease in fasting glucose and a significant increase in insulin that is likely to reduce the liver hnf-4α gene expression of t2d male wistar rats by increasing serum insulin.