the effect of resistance training with genistein on interleukin-6 and c- reactive protein in induced diabetic rats

Objective: the aim of this study was to investigate the effect of resistance training (rt) with genistein on interleukin-6 (il-6) and c-reactive protein (crp) in diabetic rats. materials and methods: 64 induced diabetic rats into 8 groups were investigated with experimental study: first week control, last week control, rt, 15 mg/kg genistein consumption, resistance exercise with 15 mg/kg genistein consumption, 30 mg/kg genistein consumption, resistance exercise with 30 mg/kg genistein consumption and placebo (dimethyl sulfoxide). rats in groups 3, 5 and 7 performed 8 weeks of rt with 30 to 100% of body weight in 3 weekly sessions, and groups 4, 5, 6, and 7 received genistein peritoneally with the mentioned doses. also, to investigate the effects of diabetes induction on the study variables, 16 healthy rats were selected and divided into two groups: healthy first week control and healthy last week control. the data were analyzed using independent sample t-tests, two-way and one-way anova with bonferroni’s post-hoc test in spss software (p-value≤ 0.05). results: rt had a significant effect on crp reduction in induced diabetic rats (p-value≤ 0.05). genistein consumption decreased il- 6 and crp in diabetic rats (p-value≤ 0.05). moreover, the interaction between rt and genistein consumption had statistically significant effects on the reduction of il-6 and crp in diabetic rats (p-value≤ 0.05); 15 mg/kg genistein consumption had a greater effect on the reduction of crp than 30 mg/kg genistein consumption in induced diabetic rats (p-value≤ 0.05). conclusion: rt alone could not significantly reduce the levels of il-6 in induced diabetic rats; however, it seems that genistein consumption with rt have interactive effects on reducing inflammatory factors in induced diabetic rats.