therapeutic intervention for caseous lymphadenitis using intra-abscess instillation of ozone or hydrogen peroxide in small ruminants

Cla is an economically and zoonotically important disease in the world. the lack of a therapeutic procedure limits the treatment mainly to surgical intervention. therapeutic efficacies of the intra-abscess instillation of o3-oil and h2o2-gly in cla in small ruminants were tested. one hundred eighty affected sheep and goats were allocated to five groups as follows: 1) nc (no intervention), 2) pc1 (injection of olive oil), 3) pc2 (injection of glycerin), 4) injection of o3-oil, 5) injection of h2o2-gly. samples of abscess contents were collected for microbiological examination prior to injection. the vas were measured on t0, then with two-week intervals on t1 and t2. on t0 and t2, vas were as nc (2.9 ± 0.5; 3.5 ± 0.5), pc1 (3.4 ± 0.7; 6.6 ± 1), pc2 (3.1 ± 0.7; 3.3 ± 0.9), o3-oil (3.3 ± 0.4; 0.4 ± 0.4), and h2o2-gly (4.6 ± 0.4, 1.5 ± 0.4). statistical analysis showed a significant decrease in vas, merely in treatment groups. cp was recovered in 48.3% of bacteriological samples. the results of this study suggested that o3-oil and h2o2-gly would be reliable therapeutic agents for treating and controlling cla. ozone showed apparently a higher  efficacy and caused more rapid shrinkage/recession of the abscesses, compared to hydrogen peroxide..