protective effect of celery ( apium graveolens l. ) essential oil on the experimental model of cuprizone-induced multiple sclerosis in male c57bl/6 mice

Considering the beneficial effects of apium graveolens l. (celery) on the nervous system, this study elucidates the protective effect of ceo on the experimental model of cuprizone-induced ms in male c57bl/6 mice. frothy mice were allocated into four experimental groups: control, cuprizone (chew pellet containing 0.2 %cpz), ceo (800 mg/kg), and cpz+ceo. animals received treatments based on their groups for 5 weeks. finally, reflexive motor behavior and serum antioxidant levels were determined. based on the findings, ambulation score, hind-limb suspension, front limb suspension, and grip strength significantly decreed in the mice treated with cpz (p < 0.05). hind limb foot angle, surface rights, and negative geotaxis significantly increased in the animals treated with cpz (p < 0.05). co-administration of cpz+ceo significantly reduced the adverse effects of cpz on ambulation score, surface righting, hind limb suspension, grip strength, and negative geotaxis (p < 0.05). co-administration of cpz+ceo significantly diminished the adverse effects of cpz on the number of crosses in the open field test and duration on the rotarod (p < 0.05). serum mda activity increased while gpx, sod, and tas decreased in the mice treated with cpz (p < 0.05). co-administration of cpz+ceo significantly reduced the adverse effects of cpz on serum antioxidant levels (p < 0.05). these results suggested the protective effect of ceo against cpz-induced ms mediated by its antioxidant activity.