Study on the immunopathologic effects of 4(3H)-quinazolinone-2- ethyl-2-phenyl ethyl (QEPE) in newborn Balb/C mice

Quinazolinones are heterocyclic and water insoluble compounds with variouspharmacological and biological characteristics (antibacterial, antiswelling, antifungal,parkinson and etc.). they are used for treatment hiv and cancer. this study investigated theeffects of 4(3h) quinazlonones-2-ethyl-2-phenyl ethyl (qepe) as a new quinazolinonscompounds on the spleen and immunocompetent cells of newborn balb/c mice. pregnantmice were divided into 3 groups (n=10) of control, sham and experimental, received distilledwater, methyl cellulose %0.05 (the solvent) and 100 mg/kg body weight (ip) of qepe (mosteffective dose), respectively, on days 8 to 15 of gestation. examinations indicated an increasein weight of spleen in experimental group. pathological studies showed increase in capsulethickness and number of macrophage cells of experimental group. statistical analysis showedsignificant differences in morphological studies between experimental, sham and controlgroups. the statistical data on capsule thickness and number of macrophage cells indicatedsignificant differences between groups. detailed observations showed an increase in thevolume of monocyte, neutrophile and eosinophile, in response to qepe, but the volume oflymphocyte and basophile were similar in experimental, control and sham groups. thedamages caused by this dose of qepe could have been the reason for the increase in thenumber of immonucompetent and macrophage cells. some studies showed damages to theorgans such as livers and hearts would lead to the increase in the thickness of spleen capsule,consequently, increase in its weight and leading to splenomegaly. so, qepe can not be anappropriate candidate for drug development. qepe in lower doses might be an appropriatecandidate for increase of immune system resistance.