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   Tumor necrosis factor α promotor polymorphism and nonsegmental vitiligo: a molecular susceptibility marker in Egyptian women  
   
نویسنده Saleh Nadia F. ,Nabil Nagla ,Bassiouny Dalia A. ,Khorshied Mervat M.
منبع journal of the egyptian women's dermatologic society - 2014 - دوره : 11 - شماره : 2 - صفحه:109 -112
چکیده    Background exchange of guanine by adenine at position –308 of the tumor necrosis factor α (tnf α ) promoter region is associated with higher serum levels of soluble tnf α and has been associated with susceptibility to a wide variety of diseases including vitiligo. objective the objective of this study was to investigate the possible association between the tnf α –308 g/a promotor polymorphism and susceptibility to nonsegmental vitiligo in egyptian women. patients and methods genotyping of tnf α –308 g/a by a pcr-rflp assay was performed for 100 female patients and 200 age-matched and sex-matched healthy controls. results the frequency of tnf α – 308 polymorphic genotypes was higher in vitiligo patients compared with controls and conferred an almost three-fold increased susceptibility to vitiligo (odds ratio 2.9, 95% confidence interval 1.56–5.36). no statistically significant differences were found between patients with the wild or the polymorphic genotypes in their clinical characteristics. conclusion tnf α – 308 g/a promotor polymorphism can be considered a genetic risk factor for nonsegmental vitiligo in egyptian women.
کلیدواژه Egypt ,females ,nonsegmental vitiligo ,tumor necrosis factor α –308 G/A
آدرس Cairo University, Faculty of Medicine, Kasr El-Ainy University Hospital, Department of Dermatology, Egypt, Cairo University, Faculty of Medicine, Kasr El-Ainy University Hospital, Department of Dermatology, Egypt, Cairo University, Faculty of Medicine, Kasr El-Ainy University Hospital, Department of Dermatology, Egypt, Cairo University, Faculty of Medicine, Kasr El-Ainy University Hospital, Department of Clinical and Chemical Pathology, Egypt
 
     
   
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