Serum vitamin D level in patients with viral warts

Background warts are a benign epithelial proliferation of the skin and mucosa that are caused by infection with human papillomavirus. topical and intralesional vitamin d administrations were used in treating viral warts, suggesting the important role of vitamin d in viral warts. objective to evaluate the serum levels of 25-hydroxyvitamin d (25-ohd) in egyptian patients diagnosed with viral warts as compared with healthy controls to investigate the potential role of vitamin d in the viral warts. patients and methods this case–control study included 40 patients with viral warts and 47 age-matched and sex-matched healthy controls. blood samples were taken from all participants for the detection of serum 25-ohd levels by enzyme-linked immunosorbent assay. results the present study showed a statistically significant decrease in the serum 25-ohd levels in patients with viral warts when compared with controls (p =0.001). in addition, there was a statistically significant difference between patients and controls regarding vitamin d status (p =0.001), as patients with viral warts had a more deficient pattern of vitamin d status than controls. conclusion the present study showed significantly low levels of serum vitamin d in patients with viral warts, explaining the role of vitamin d in topical and intralesional therapy.