Synthesis and Antimicrobial Evaluation of Some New Heterocyclic Compounds From Thienopyridines and Thienopyrimidine Derivatives

4-aryl-3-cyano-5-ethoxycarbonyl-6-methyl pyridine-2-(1h)-thiones 1a,b were prepared and reacted with chloroacetonitrile to furnish 3-amino-4-aryl-2-carbamoyl-5-ethoxycarbonyl-6- methyl thieno[2,3-b]pyridine derivative 3a,b. the reaction of 3a with a variety of reagent namely, ethylenediamine, sodium azide, tri ethylorthoformate, 4-chlorobenzaldehyde, carbondisulfide and sodium nitrous acid have been carried out and their products were identified . most of these products were subjected to further reaction to obtain heterocyclic compounds. the all synthesized derivatives displayed good antimicrobial activities against some species of bacteria as ( e.colie, p.seudemones and s.aurous) and some species of fungal as (aspergillus, pencillium and clado).