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Development of a RP-HPLC method for evaluation of in vitro permeability of voriconazole in the presence of enhancers through rat skin
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نویسنده
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vamsi krishna m. ,dash r.n. ,venugopal p. ,reddy b.j. ,sandeep p. ,madhavi g.
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منبع
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journal of saudi chemical society - 2017 - دوره : 21 - شماره : 1 - صفحه:1 -10
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چکیده
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An isocratic rp-hplc–uv method for the analysis of voriconazole in skin diffusate samples has been developed and validated. experimental design was employed to optimize the method. the method was validated as per ich guidelines. linearity was observed over the concentration range of 2–100 μg ml−1 (r2 = 0.999). limits of detection and quantification were 0.6 and 2 μg ml−1,respectively. intra-day and inter-day precision (% rsd) was within the ich limits (⩽2%). the method was successfully used to analyze skin diffusate samples,and the effectiveness of different permeation enhancers was compared with respect to flux and permeability coefficient. © 2013
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کلیدواژه
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Permeation enhancers; RP-HPLC; Skin diffusate samples; Voriconazole
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آدرس
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sree vidyanikethan college of pharmacy,tirupathi, India, alliance institute of advanced pharmaceutical and health sciences,ameerpet,hyderabad, India, alliance institute of advanced pharmaceutical and health sciences,ameerpet,hyderabad, India, alliance institute of advanced pharmaceutical and health sciences,ameerpet,hyderabad, India, alliance institute of advanced pharmaceutical and health sciences,ameerpet,hyderabad, India, sree vidyanikethan college of pharmacy,tirupathi, India
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Authors
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