Highly efficient three-component synthesis of 5-substituted-1H-tetrazoles from aldehydes,hydroxylamine,and tetrabutylammonium azide using doped nano-sized copper(I) oxide (Cu2O) on melamine–formaldehyde resin

A simple and facile one-pot three-component synthesis of 5-substituted 1h-tetrazole derivatives from aldehydes catalyzed by doped nano-sized cu2o on melamine–formaldehyde resin (nano-cu2o–mfr) is described. in this protocol,treatment of structurally diverse aldehydes,hydroxylamine hydrochloride and tetrabutylammonium azide (tbaa) as an azide source in the presence of nano-cu2o–mfr as an efficient heterogeneous nano-catalyst affords the corresponding 5-substituted 1h-tetrazoles in good to excellent yields. the influence of different parameters on the progress of reaction was studied. the nano-cu2o–mfr is a cheap and stable nano-catalyst that could be easily prepared,recycled and reused for many consecutive reaction runs without significant decrease in its activity. © 2016 king saud university