Synthetic approaches to benzimidazoles from o-phenylenediamine: A literature review

The methods for the synthesis of benzimidazoles have become a focus of synthetic organic chemists,as they are useful building blocks for the development of important therapeutic compounds in medicine. benzimidazole nucleus plays a very important role as a therapeutic agent e.g. antiulcer and anthelmintic drugs. other benzimidazole derivatives exhibit pharmacological activities such as antimicrobial,antiviral,anticancer,anti-inflammatory and analgesic. © 2016 king saud university