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Practical synthesis of methyl 7-(3-hydroxy-5-oxocyclopent-1-en-1-yl)-heptanoate
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نویسنده
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jiang x. ,wang x. ,huang x. ,li g. ,yu c.
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منبع
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journal of saudi chemical society - 2017 - دوره : 21 - شماره : 5 - صفحه:587 -592
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چکیده
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The key intermediate of misoprostol,methyl 7-(3-hydroxy-5-oxocyclopent-1-en-1-yl)-heptanoate was prepared from commercially available suberic acid in 40% yield over five steps. the key step involved a zncl2 catalyzed friedel-crafts reaction between furan and 2,9-oxonanedione. sulfuric acid catalyzed methylation of 8-(furan-2-yl)-8-oxooctanoic acid followed by sequential reduction and zncl2 catalyzed piancatelli rearrangement resulted in the formation of the key intermediate of misoprostol. © 2017 king saud university
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کلیدواژه
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Dehydrate cyclization; Friedel-Crafts acylation; Misoprostol; Piancatelli rearrangement
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آدرس
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college of pharmaceutical sciences,zhejiang university of technology, China, collaborative innovation center of yangtze river delta region green pharmaceuticals,college of pharmaceutical sciences,zhejiang university of technology, China, collaborative innovation center of yangtze river delta region green pharmaceuticals,college of pharmaceutical sciences,zhejiang university of technology, China, collaborative innovation center of yangtze river delta region green pharmaceuticals,college of pharmaceutical sciences,zhejiang university of technology, China, college of pharmaceutical sciences,zhejiang university of technology,hangzhou,china,collaborative innovation center of yangtze river delta region green pharmaceuticals,college of pharmaceutical sciences,zhejiang university of technology, China
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Authors
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