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Synthesis,characterization,antimicrobial and anticancer studies of new steroidal pyrazolines
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نویسنده
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shamsuzzaman department of chemistry ,khanam h. ,dar a.m. ,siddiqui n. ,rehman s.
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منبع
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journal of saudi chemical society - 2016 - دوره : 20 - شماره : 1 - صفحه:7 -12
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چکیده
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A convenient synthesis of 2'-(2″,4″-dinitrophenyl)-5α-cholestano [5,7-c d] pyrazolines 4-6 from cholest-5-en-7-one 1-3 was performed and structural assignment of the products was confirmed on the basis of ir,1h nmr,13c nmr,ms and analytical data. the synthesized compounds were screened for in vitro antimicrobial activity against different strains during which compound 6 showed potent antimicrobial behaviour against corynebacterium xerosis and staphylococcus epidermidis. the synthesized compounds were also screened for in vitro anticancer activity against human cancer cell lines during which compound 5 exhibited significant anticancer activity. © 2012 king saud university. production and hosting by elsevier b.v.
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کلیدواژه
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4-Dinitrophenylhydrazine; Anticancer; Antimicrobial; Cholest-5-en-7-one; Pyrazoline
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آدرس
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aligarh muslim university, India, department of chemistry,aligarh muslim university, India, department of chemistry,aligarh muslim university, India, department of illmul advia,ajmal khan tibbiya college,aligarh muslim university, India, department of illmul advia,ajmal khan tibbiya college,aligarh muslim university, India
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Authors
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