Biological evaluation of potent antioxidant,lipoxygenase inhibitor and antibacterial: A comparative study

Three biologically active new schiff bases,2-[(3-hydroxybenzylidene)amino]phenol 5,2-[(4-hydroxybenzylidene)amino]phenol 6 and 4-[(2-hydroxyphenylimino)methyl]benzene-1,3-diol 7,were synthesized by the reaction of 2-aminophenol 1 with three different hydroxyl-benzaldehydes 2-4. they were characterized by spectroscopic analysis (ir,1h nmr,ei-ms) along with elemental analyses. the products were biological screened out for antioxidant,lipoxygenase inhibition,antibacterial and urease inhibition activities. the compounds 5 and 6 showed potent while 7 showed moderate antioxidant activity. compound 6 showed potent whereas 5 and 7 showed significant lipoxygenase inhibition activity. all the target compounds showed excellent activities against staphylococcus intermedius,bacillus subtilis,staphylococcus aureus,escherichia coli and salmonella typhi bacteria. all the compounds showed non-significant activity against urease enzyme. © 2012 king saud university. production and hosting by elsevier b.v.