Regioselective synthesis of anilines and β-dibrominated acetamides from N-aryl acetoacetamides mediated by Cu(I) salts

A highly regioselective synthetic strategy mediated by cu(i) salts is presented for the synthesis of anilines and β-dibrominated acetamides from n-aryl acetoacetamides. a variety of n-aryl acetoacetamides were used in this protocol,and a wide range of polysubstituted anilines and β-dibrominated acetamides were obtained in moderate to good yields. when employing cui as the additive in this strategy,anilines are obtained,however,when using cubr as the partner of cui under a mild condition,β-dibrominated acetamides are afforded. © 2014 king saud university.