Brønsted acidic ionic liquid catalyzed synthesis of poly-substituted hydroquinolines through diastereoselective,one-pot and pseudo-eight-component reaction

We have developed an efficient diastereoselective synthesis of poly-substituted hydroquinolines from commercially available starting materials,meldrum's acid,aromatic aldehydes and arylamines,in a simple and one-pot reaction using brønsted acidic ionic liquid (4-sulfobutyl)-tris(4-sulfophenyl) phosphonium hydrogen sulfate. these three materials react together through pseudo-eight-components reaction to generate complex products with four stereocenters that involves ten new bond formations. this synthetic method can be a combination of knoevenagel and michael reactions. © 2014 production and hosting by elsevier b.v.