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Synthesis and pharmacological evaluation of 5-methyl-2-phenylthiazole-4-substituted heteroazoles as a potential anti-inflammatory and analgesic agents
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نویسنده
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thore s.n. ,gupta s.v. ,baheti k.g.
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منبع
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journal of saudi chemical society - 2016 - دوره : 20 - شماره : Supplement 1 - صفحه:S46 -S52
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چکیده
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A series of novel 5-methyl-2-phenylthiazole-4-substituted-heteroazole derivatives (6–15) have been synthesized. the structures of these compounds were established by ir,1hnmr,mass spectral data and elemental analyses. compounds were evaluated for their anti-inflammatory and analgesic activities as well as gastric ulcerogenic effects. derivatives 9,10,14 and 15 exhibited moderate to good anti-inflammatory and analgesic activities in carrageenan-induced rat paw edema and acetic acid-induced writhing in mice respectively,with low ulcerogenicity compared with the standard drug diclofenac sodium. © 2012
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کلیدواژه
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Analgesic; Anti-inflammatory; Diclofenac sodium; NSAIDs; Thiazole; Ulcerogenic potential
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آدرس
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deogiri college,padampura, India, deogiri college,padampura, India, y.b. chavan college of pharmacy,rafiq zakaria campus, India
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Authors
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