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Molecular docking of Diospyrin as a LOX inhibitory compound
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نویسنده
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uddin g. ,rauf a. ,arfan m. ,waliullah institute of chemical sciences ,rehman t.u. ,khan a.z. ,ali g. ,rehman b. ,zia-ul-haq m.
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منبع
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journal of saudi chemical society - 2016 - دوره : 20 - شماره : Supplement 1 - صفحه:S448 -S450
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چکیده
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Diospyros lotus is traditionally used in various diseases including inflammation. in the current study an effort has been made to identify a bioactive constituent from d. lotus in order to scientifically validate its use in inflammatory disorders. diospyrin was isolated from d. lotus and exhibited significant lipoxygenase (lox) inhibitory activity (ic50 value: 31.89 ± 0.14 μmol). molecular docking revealed significant molecular interactions between diospyrin and lox showing promising potential for further optimization as a potential anti-inflammatory lead compound. © 2013
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کلیدواژه
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Diospyrin; Diospyros lotus; Docking; Inflammation; Lipoxygenase
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آدرس
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institute of chemical sciences,university of peshawar,peshawar, Pakistan, institute of chemical sciences,university of peshawar,peshawar, Pakistan, institute of chemical sciences,university of peshawar,peshawar, Pakistan, university of peshawar,peshawar, Pakistan, institute of chemical sciences,university of peshawar,peshawar, Pakistan, department of pharmacy,university of peshawar,peshawar, Pakistan, department of pharmacy,university of peshawar,peshawar, Pakistan, department of pharmacy,university of peshawar,peshawar, Pakistan, department of pharmacognosy,university of karachi, Pakistan
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Authors
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