Glycerol as a green solvent for efficient,one-pot and catalyst free synthesis of 2,4,5-triaryl and 1,2,4,5-tetraaryl imidazole derivatives

A simple,efficient and catalyst-free method has been developed for the synthesis of 2,4,5-triaryl and 1,2,4,5-tetraaryl imidazole derivatives in glycerol as green solvent at 90 °c. it is noteworthy that in this protocol the yields of products were comparable to or better than,those in conventional media. the use of green reaction media makes this methodology simple,safe and cost-effective. © 2013 king saud university