Synthesis and anti-inflammatory activity of some new 1,3,4-thiadiazoles containing pyrazole and pyrrole nucleus

A new series of 1,3,4-thiadiazole with pyrazole-3-carboxamides (3a–f) and pyrrole-3-carboxamide (4a–f) moiety are prepared using intermediate compounds 1,3,4-thiadiazolacrylamides (2a–f). the structures of newly synthesized compounds were confirmed on the basis of their 1h nmr,13c nmr,lcms mass,ft-ir and elemental analysis data results. among all the compounds (12),seven compounds were found to exhibit significant anti-inflammatory activity with 77.27,75.89,76.24,68.55,63.72,57.41,53.05% and 81.00,80.55,78.62,71.45,68.95,61.89,56.32% inhibition in paw edema at 3 h and 5 h respectively,compared to the standard drug indomethacin (74.82 and 80.32% at 3 h and 5 h). compounds 3c,3d and 4c exhibited potent activity than standard drug. © 2012