Synthesis,spectral analysis and anti-bacterial study of N-substituted derivatives of 2-(5-(1-(phenylsulfonyl)piperidin-4-yl)-1,3,4-oxadiazol-2-ylthio)acetamide

1,3,4-oxadiazole bearing compounds are one of the most attractive class for researchers due to their biological activities. in the undertaken research,a number of n-substituted derivatives of 2-(5-(1-(phenylsulfonyl)piperidin-4-yl)-1,3,4-oxadiazol-2-ylthio)acetamide (6a–n) were synthesized through a series of steps. the reaction of benzenesulfonyl chloride with ethyl isonipecotate yielded ethyl 1-(phenylsulfonyl)piperidin-4-carboxylate (1),which was further converted into 1-(phenylsulfonyl)piperidin-4-carbohydrazide (2) and 5-(1-(phenylsulfonyl)piperidin-4-yl)-1,3,4-oxadiazol-2-thiol (3) respectively. the target compounds 6a–n were synthesized by the reaction of compound 3 with different n-aralkyl/aryl substituted 2-bromoacetamides (5a–n) in the presence of a weak base and polar aprotic solvent. the structures of the synthesized compounds were elucidated through 1h-nmr,ir and mass spectral data. the synthesized compounds were screened against gram-negative and gram-positive bacteria and exhibited moderate to talented activity. © 2013