Synthesis of new N-(5-chloro-2-methoxyphenyl)-4-(5-substituted-1,3,4-oxadiazol-2-ylthio)butanamide derivatives as suitable lipoxygenase inhibitors

Heterocyclic compounds are the most attractive class for researchers due to their biological activities. in the undertaken research,a number of n-(5-chloro-2-methoxyphenyl)-4-(5-substituted-1,3,4-oxadiazol-2-ylthio)butanamide (6a–k) compounds were prepared by converting multifarious phenyl/aryl/aralkyl/heterocyclic organic acids (1a–k) consecutively into the corresponding esters (2a–k),hydrazides (3a–k) and 5-substituted-1,3,4-oxadiazol-2-thiols (4a–k). finally,the target compounds 6a–k were synthesized by stirring 5-substituted-1,3,4-oxadiazol-2-thiols (4a–k) with n-(5-chloro-2-methoxyphenyl)-4-bromobutanamide (5) in the presence of n,n-dimethylformamide (dmf) and sodium hydride (nah). the structure elucidation of the synthesized compounds was processed through 1h-nmr,ir and mass spectral data. the synthesized compounds were screened against lipoxygenase enzyme (lox) and showed moderately good activities relative to the reference standard baicalein. © 2013 king saud university