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Synthesis,characterization and biological evaluation of 4-oxo-thiazolidine compounds
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نویسنده
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godhani d.r. ,jogel a.a. ,dobariya p.b. ,sanghani a.m.
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منبع
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journal of saudi chemical society - 2016 - دوره : 20 - شماره : Supplement 1 - صفحه:S523 -S535
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چکیده
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A series of compounds 4-oxo-thiazolidine derivatives aj5a–j were synthesized by condensation reactions. the structure of synthesized compounds was characterized by ir,1h nmr,13c nmr and mass spectroscopy. the present paper deals with newly synthesized thiazolidine compounds aj5a–aj5j that were screened for their antimicrobial activity against different strains of bacteria and fungi using serial broth dilution method (mueller–hinton broth dilution method). in vitro antitubercular activity of compounds aj5a–j was carried out against mycobacterium tuberculosis h37rv. compounds aj5a,aj5d,aj5e,aj5f and aj5g were found most active against selected bacterial strains (mic = 62.5 μg/ml) and compounds aj5a–j were found moderately active against m. tuberculosis. © 2013
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کلیدواژه
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4-Oxo-thiazolidine; Antibacterial activity; Antifungal activity; Antitubercular activity
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آدرس
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department of chemistry,dst-fist sponsored,mahatma gandhi campus,maharaja krishnakumarsinhji bhavnagar university,bhavnagar, India, department of chemistry,dst-fist sponsored,mahatma gandhi campus,maharaja krishnakumarsinhji bhavnagar university,bhavnagar, India, department of chemistry,dst-fist sponsored,mahatma gandhi campus,maharaja krishnakumarsinhji bhavnagar university,bhavnagar, India, chemistry department,sir p.p. institute of science,bhavnagar, India
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Authors
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