3D QSAR,pharmacophore indentification studies on series of 1-(2-ethoxyethyl)-1H-pyrazolo [4,3-d]pyrimidines as phosphodiesterase V inhibitors

Context: in recent years phosphodiesterase v acts as an attractive target for cardiovascular drug design and qsar techniques are helpful for the optimization of structural requirements for designing novel compounds. objective: the present communication deals with 3d-qsar analysis of 1-(2-ethoxyethyl)-1h-pyrazolo[4,3-d]pyrimidines as phosphodiesterase v inhibitors. materials and methods: the multiple linear regression analysis and knn-mfa analysis were carried out on 33 reported 1-(2-ethoxyethyl)-1h-pyrazolo[4,3-d]pyrimidines in vlife mds 3.5. results: the substitution of electron withdrawing groups in pyrazole ring and sterically less bulkier groups is important for the phosphodiesterase v inhibition indicated by both qsar analyses. conclusion: the two different qsar models are generated by using two different principles,both the models are showing similar results which indicate that this knn-mfa technique can be utilized for cross validation of the results of multiple linear regression studies. © 2012.