An efficient synthesis of β-amino ketone compounds through one-pot three-component Mannich-type reactions using bismuth nitrate as catalyst

Three components one-pot mannich reaction of aromatic ketone,aromatic aldehyde and aromatic amines has been efficiently catalyzed by recyclable bismuth nitrate (bi(no3)3,bn) at ambient temperature to give various β-amino carbonyl compounds in high yields. this method has advantages of mild condition,no environmental pollution,and simple work-up procedures. most importantly,β-amino carbonyl compounds with ortho-substituted aromatic amines are obtained in acceptable to moderate yields by this methodology. © 2012 production and hosting by elsevier b.v.