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Synthesis and antimicrobial screening of tetra Schiff bases of 1,2,4,5-tetra (5-amino-1,3,4-thiadiazole-2-yl)benzene
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نویسنده
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yousif e. ,rentschler e. ,salih n. ,salimon j. ,hameed a. ,katan m.
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منبع
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journal of saudi chemical society - 2014 - دوره : 18 - شماره : 3 - صفحه:269 -275
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چکیده
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In the present study,novel tetra schiff bases were synthesized by condensation of 1,2,4,5-tetra (5-amino-1,3,4-thiadiazole-2-yl)benzene with different aromatic aldehydes. the chemical structures were confirmed by means of ir,1h nmr,13c nmr,and elemental analysis. all compounds were screened for antibacterial (staphylococcus aureus atcc-9144,staphylococcus epidermidis atcc-155,micrococcus luteus atcc-4698,bacillus cereus atcc-11778,escherichia coli atcc-25922,and pseudomonas aeruginosa atcc-2853) and antifungal (aspergillus niger atcc-9029 and aspergillus fumigatus atcc-46645) activities by paper disc diffusion technique. the minimum inhibitory concentrations (mics) of the compounds were also determined by agar streak dilution method. among the synthesized compounds 1,2,4,5-tetra[5-(4-nitrobenzylideneamino)-1,3,4-thiadiazole-2-yl]benzene 7 was found to be the most potent antimicrobial activity with mics of 3.4,2.1,1.2,2.0,3.1,2.4,1.1,and 1.7μg/ml against the above mentioned respective strains. © 2011.
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کلیدواژه
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4-Thiadiazole; Antibacterial; Antifungal; Tetra Schiff base
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آدرس
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department of chemistry,college of science,al-nahrain university, Iraq, institute of inorganic and analytical chemistry,johannes gutenberg university of mainz,duesbergweg 10-14, Germany, Universiti Kebangsaan Malaysia, Malaysia, Universiti Kebangsaan Malaysia, Malaysia, department of chemistry,college of science,al-nahrain university, Iraq, department of chemistry,college of science,al-nahrain university, Iraq
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Authors
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