Synthesis and antimicrobial screening of tetra Schiff bases of 1,2,4,5-tetra (5-amino-1,3,4-thiadiazole-2-yl)benzene

In the present study,novel tetra schiff bases were synthesized by condensation of 1,2,4,5-tetra (5-amino-1,3,4-thiadiazole-2-yl)benzene with different aromatic aldehydes. the chemical structures were confirmed by means of ir,1h nmr,13c nmr,and elemental analysis. all compounds were screened for antibacterial (staphylococcus aureus atcc-9144,staphylococcus epidermidis atcc-155,micrococcus luteus atcc-4698,bacillus cereus atcc-11778,escherichia coli atcc-25922,and pseudomonas aeruginosa atcc-2853) and antifungal (aspergillus niger atcc-9029 and aspergillus fumigatus atcc-46645) activities by paper disc diffusion technique. the minimum inhibitory concentrations (mics) of the compounds were also determined by agar streak dilution method. among the synthesized compounds 1,2,4,5-tetra[5-(4-nitrobenzylideneamino)-1,3,4-thiadiazole-2-yl]benzene 7 was found to be the most potent antimicrobial activity with mics of 3.4,2.1,1.2,2.0,3.1,2.4,1.1,and 1.7μg/ml against the above mentioned respective strains. © 2011.