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   Kinetics of the alkaline hydrolysis of isatin and N-methylisatin in water and water-N,N-dimethylacetamide mixtures  
   
نویسنده Radman Ramyah F. ,Ismail Amel M. ,Al-Jallal Nada A.
منبع journal of saudi chemical society - 2010 - دوره : 14 - شماره : 2 - صفحه:223 -229
چکیده    The kinetics of amide bond cleavage of isatin and n-methylisatin in the presence of n,ndimethylacetamide (dma) was followed spectrophotometrically in the range of solvent composition (0–48.53 wt.%) and temperatures (40–70 ˚c) using piperidine as a nucleophile. the reaction was studied under pseudo-first-order kinetics. the rate of the reaction decreases largely with increasing organic solvent content. the thermodynamic activation parameters were calculated and discussed in terms of solvation of the activated complex. no linearity was observed between log rate constant and the reciprocal dielectric constant for the solvent used suggesting that there is a selective solvation by higher polar solvent (water). finally, a mechanism for the ring opening for isatin and n-methylisatin was proposed.
کلیدواژه Alkaline hydrolysis; Isatin; Bond cleavage; Nucleophile; Pseudo-first-order kinetics; Thermodynamic activation parameters; Indole; Central nervous system; Entropy of activation
آدرس King Saud University (KSU), Faculty of Science, Chemistry Department, Saudi Arabia, King Saud University (KSU), Faculty of Science, Chemistry Department, Saudi Arabia, King Saud University (KSU), Faculty of Science, Chemistry Department, Saudi Arabia
 
     
   
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